Urinary tract infections in the elderly: a review of disease characteristics and current treatment options

Rodriguez-Mañas L. Urinary tract infections in the elderly: a review of disease characteristics and current treatment options. Drugs in Context 2020; 9: 2020-4-13. DOI: 10.7573/dic.2020-4-13. Free PMC article.

Despite the high prevalence of UTIs in the elderly, treatment options are limited. Although the medical community may agree in principle about the need for rational antibiotic usage, the absence of effective alternatives to treat UTIs can be a genuine barrier to change. Elderly patients are not only more prone to UTIs but are also more likely to have comorbidities and require multiple medications. The option to use a device that acts in a physical manner (barrier effect) without pharmacological properties, and with potential to reduce antimicrobial use, has obvious appeal in this patient population.

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Xyloglucan, hibiscus and propolis to reduce symptoms and antibiotics use in recurrent UTIs: a prospective study.

Cai T et al. Future Microbiol. 2019 Aug;14:1013-1021.

The results of a new prospective observational clinical trial carried out in women with recurrent Urinary Tract Infections (rUTIs) have demonstrated that the use of a medical device containing xyloglucan, hibiscus and propolis reduces both recurrences and the use of antibiotics. Moreover, the study showed remarkable results since almost 84% of patients reported a notable clinical improvement of QoL with a statistically significant difference compared with baseline after 6 months from the beginning of the treatment. It is also concluded that although antibiotics are still considered the pillar for the management of UTIs, the spread of multidrug-resistant microorganisms is worryingly rising and requires thorough monitoring and novel preventive approaches. This is an independent study, coordinated by Dr. Tommaso Cai, member of the board of EAU Guidelines and part of several other Italian and international institutions that, since a long time, are fully committed in the rationalisation of the use of antibiotics.

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